³Ô¹Ïtv

Areas of interest

Clinical Phenotyping of Dementia Syndromes

Our research aims to enhance the clinical characterisation of dementia syndromes, including Alzheimer’s disease and frontotemporal dementia. We integrate neuropsychological assessment with neuroimaging techniques to identify and define early cognitive changes. Through detailed phenotyping, we seek to delineate disease subtypes, inform the development of sensitive diagnostic tools, and establish reliable biomarkers to track disease progression, critical for both clinical trials and personalised care pathways.

Mapping Symptomatology in Posterior Cortical Atrophy

Posterior cortical atrophy (PCA) is a neurodegenerative condition marked by progressive visuospatial and visuo-perceptual impairments that are not explained by ocular pathology. While visual disturbances are hallmark features, our research highlights the presence and diagnostic relevance of non-visual symptoms in early disease stages. We focus particularly on the roles of attention and altered visual imagery in shaping the cognitive profile of PCA, with the goal of refining diagnostic accuracy and improving symptom management.

Markers of Cognitive Change in Healthy Older APOE4 Carriers

Individuals carrying the APOE ε4 allele are at elevated risk for developing cognitive decline and Alzheimer’s disease in later life. Our research investigates early indicators of cognitive vulnerability in this population, with a focus on subjective cognitive decline - self-perceived changes in memory or thinking abilities. By longitudinally tracking these subjective experiences alongside functional changes in posterior parietal regions, we aim to uncover early markers of neurodegeneration before measurable clinical symptoms emerge.